Shaopeiwen Luo

Focus Areas

Research Interests

Multi-Omics Integration

Transcriptomics Metabolomics Proteomics Genomics

Single-Cell RNA-seq

Atlas Integration Cell Fate Transition GRN

Machine Learning for Biomedicine

Virtual Cell Modeling Disease Modeling

Disease Mechanisms

Autism Neural Developmental Disorders

CRISPR & Functional Genomics

gRNA Library Screening High Throughput Validation

Clinical Application

Biomarker Discovery Disease Prevention Drug Development

Latest

News & Updates

2026 🤖 Developing RegStatusNet, an AI model for cell regulatory status prediction combining transcriptomics and metabolomics signals.

Nov 2025 Published Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila in Nature Communications

xxxxxxxxxxxxxxxxxxxx 🎓 Graduated from the Duke-NUS IBM programme — completing the Integrative Biomedical PhD journey. Milestone

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Research Output

Selected Publications

2025-2026

Manuscript in preparation

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Preprint Coming Soon

Manuscript in preparation

Cell Type Classification Pipeline for Neural Stem Cell Identification in Human Brain Single-Cell RNA-seq atlas

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Coming Soon

Manuscript under review

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Coming Soon [Code]

Nature Communications

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Jiaen Lin, Qiannan Deng, Hongyan Wang, et al.

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2020-2024

Nature Communications

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Science Advances

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Full publication list → Google Scholar

Career

Experience

2025 – Present

Research Fellow

Duke-NUS Medical School · Singapore

Multi-omics integration, CRISPR gRNA library screening, machine learning models for disease marker discovery. PI: Prof. Hongyan Wang.

2020 – 2025

PhD Student

Duke-NUS IBM Programme · Singapore

Single-cell and bulk RNA-seq pipelines, and Microprotein research in brain development and neural stem cell biology.

Academic

Education

2020 – Aug 2025

PhD, Integrated Biology and Medicine

Duke-NUS Medical School

Graduated August 2025. Research on neural stem cell biology and multi-omics.

Before 2020

Bachelor Degree

Huazhong University of Science and Technology

Bachelor's degree in Neuroscience.

Technical

Skills & Tools

Languages

PythonRBash

Single cell transcriptomics

scRNA-seq analysis Spatial Omics data integration

Multi-omics

Proteomics ChIP-seq analysis Metabolomics Bulk RNA-seq

Machine Learning

MLPCNN GNN Transformer

HPC computing

GitLinux/HPCSnakemake

Molecular biology

Fly Genetics Confocal imaging Western Blot Cell Culture

Get In Touch

Contact

I'm open to collaborations in multi-omics data integration, AI/ML for biomedical research, and translational studies. Feel free to reach out for research discussions or potential positions.

📍 Singapore

jiaenlin999@gmail.com Github LinkedIn Profile Google Scholar